JAM-C regulates unidirectional monocyte transendothelial migration in inflammation.

نویسندگان

  • Paul F Bradfield
  • Christoph Scheiermann
  • Sussan Nourshargh
  • Christiane Ody
  • Francis W Luscinskas
  • G Ed Rainger
  • Gerard B Nash
  • Marijana Miljkovic-Licina
  • Michel Aurrand-Lions
  • Beat A Imhof
چکیده

Monocyte recruitment from the vasculature involves sequential engagement of multiple receptors, culminating in transendothelial migration and extravasation. Junctional adhesion molecule-C (JAM-C) is localized at endothelial intercellular junctions and plays a role in monocyte transmigration. Here, we show that blockade of JAM-B/-C interaction reduced monocyte numbers in the extravascular compartment through increased reverse transmigration rather than by reduced transmigration. This was confirmed in vivo, showing that an anti-JAM-C antibody reduced the number of monocytes in inflammatory tissue and increased the number of monocytes with a reverse-transmigratory phenotype in the peripheral blood. All together, our results suggest a novel mechanism of reducing accumulation of monocytes at inflammation sites by disruption of JAM-C-mediated monocyte retention.

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عنوان ژورنال:
  • Blood

دوره 110 7  شماره 

صفحات  -

تاریخ انتشار 2007